Hubrecht Institute publications

Key suppresSTEM publications • Hubrecht Institute

Van de Wetering, M. et al (2015). Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161: 933-945. PMID: 25957691.

Sato, T. and H. Clevers (2013). Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340: 1190-1194. PMID: 23744940.

Peng, W. C., W. de Lau, et al. (2013). Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Rep 3: 1885-1892. PMID: 23809763.

Clevers, H. (2013). The intestinal crypt, a prototype stem cell compartment. Cell 154: 274-284. PMID: 23809763.

Sato, T., J. H. van Es, et al. (2011). Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418. PMID: 21113151.

de Lau, W., N. Barker, et al. (2011). Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476: 293-297. PMID: 21727895.

Barker, N., M. Huch, et al. (2010). “Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.” Cell Stem Cell 6: 25-36. PMID: 20085740.

Sato, T., R. G. Vries, et al. (2009). Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262-265. PMID: 19329995.

Barker, N., J. H. van Es, et al. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007. PMID: 17934449.

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